Lettuce in nowadays is one of the main agricultural export product in Taiwan, although the production of lettuce was not common before 2002. Due to the weather condition in central Taiwan during winter season is favorable for lettuce, this industry grows vividly during the past 20 years. However, the lettuce is facing different aspects of challenge of which restrict the development. The first challenge is the shortage and aging of labor force that requires field machine to reduce the labor demand. Due to the customer’s demand on product accreditation, it need more labor inputs for field records. Moreover, the increase of costs, plant disease and pest management, the saturation of export market, post-harvest and cold chain techniques is close related to the development of industry. In views of this, the smart production system is introduce to enhance the lettuce industry. The establishment of ridge making and fertilization sync technique saves the fertilizer application in 50% and reduce the labor cost than the traditional transplanting. The development lettuce growth model served as foundation for smart production system to increase the accuracy of field management. In terms of pest monitoring, we develop automatic pest trap monitoring instrument to reduce labor monitoring and improve the accuracy of pest population dynamic monitoring. This monitoring provides basis for accurate pest control to reduce the pesticide abuse. The iPLANT system, information system for accreditation information collection, integrates field operation, irrigation channel, soil information and pest warning, helps industry to increase the integrity of production history and reduce the labor requirement of paper work for 50%. The post-harvest cold chain transportation technique for middle-east area is complete to overcome the transportation restriction. In 2021, the container was successfully sent to middle-east market. This successful opens new opportunity to overcome the saturation of existing export market. Under the close cooperation of public and private sector, the lettuce industry is featured with smart technology step by step to transform into knowledge intensive industry from labor intense industry.